Arnold R Gammaitoni Selected Research

Myoclonic Epilepsies (Myoclonic Encephalopathy)

11/2023	Fenfluramine increases survival and reduces markers of neurodegeneration in a mouse model of Dravet syndrome.
10/2023	Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo-controlled clinical trial.
1/2023	Fenfluramine treatment is associated with improvement in everyday executive function in preschool-aged children (<5 years) with Dravet syndrome: A critical period for early neurodevelopment.
1/2023	Fenfluramine treatment for Dravet syndrome: Caregiver- and clinician-reported benefits on the quality of life of patients, caregivers, and families living in Germany, Spain, Italy, and the United Kingdom.
7/2022	Long-term cardiovascular safety of fenfluramine in patients with Dravet syndrome treated for up to 3 years: Findings from serial echocardiographic assessments.
1/2022	Fenfluramine treatment for dravet syndrome: Real-world benefits on quality of life from the caregiver perspective.
1/2022	Fenfluramine significantly reduces day-to-day seizure burden by increasing number of seizure-free days and time between seizures in patients with Dravet syndrome: A time-to-event analysis.
12/2021	Impact of fenfluramine on the expected SUDEP mortality rates in patients with Dravet syndrome.
8/2021	An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies.
1/2021	Improved everyday executive functioning following profound reduction in seizure frequency with fenfluramine: Analysis from a phase 3 long-term extension study in children/young adults with Dravet syndrome.

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Arnold R Gammaitoni Research Topics

Disease

22	Pain (Aches) 07/2015 - 12/2002
11	Myoclonic Epilepsies (Myoclonic Encephalopathy) 11/2023 - 10/2018
8	Neuralgia (Stump Neuralgia) 04/2013 - 01/2004
7	Low Back Pain (Lumbago) 04/2011 - 03/2003
6	Seizures (Absence Seizure) 11/2023 - 08/2021
5	Osteoarthritis 05/2010 - 01/2004
4	Lennox Gastaut Syndrome 01/2023 - 10/2018
3	Shoulder Impingement Syndrome 07/2015 - 01/2014
3	Postherpetic Neuralgia 01/2004 - 12/2002
2	Sudden Unexpected Death in Epilepsy 01/2023 - 12/2021
2	Knee Osteoarthritis 04/2011 - 07/2008
2	Carpal Tunnel Syndrome 11/2006 - 08/2006
2	Chronic Pain 01/2004 - 03/2003
1	Gliosis 11/2023
1	Neuroinflammatory Diseases 11/2023
1	Sleepiness 10/2023
1	Fever (Fevers) 10/2023
1	Tendinopathy (Tendonitis) 01/2013
1	Peripheral Nervous System Diseases (PNS Diseases) 10/2012
1	Hyperalgesia 12/2006
1	Diabetic Neuropathies (Diabetic Neuropathy) 01/2004
1	Postoperative Pain 03/2003
1	Acute Pain 03/2003
1	Wounds and Injuries (Trauma) 03/2003

Drug/Important Bio-Agent (IBA)

16	Lidocaine (Xylocaine)FDA LinkGeneric 07/2015 - 12/2002
13	FenfluramineIBA 11/2023 - 10/2018
12	Analgesics (Analgesic Drugs)IBA 10/2012 - 12/2002
4	Tetracaine (Amethocaine)FDA LinkGeneric 07/2015 - 01/2013
3	Adrenal Cortex Hormones (Corticosteroids)IBA 07/2015 - 01/2014
3	Opioid Analgesics (Opioids)IBA 02/2009 - 03/2003
2	Pregabalin (Lyrica)FDA Link 04/2013 - 10/2012
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 05/2010 - 12/2008
2	oxycodone-acetaminophen (Percocet)FDA LinkGeneric 03/2003 - 03/2003
2	Oxycodone (Oxycontin)FDA LinkGeneric 03/2003 - 03/2003
2	Acetaminophen (Paracetamol)FDA LinkGeneric 03/2003 - 03/2003
2	Lidoderm FDA Link 02/2003 - 12/2002
1	stiripentolIBA 10/2023
1	Blood Glucose (Blood Sugar)IBA 10/2023
1	Sigma-1 ReceptorIBA 08/2021
1	Serotonin (5 Hydroxytryptamine)IBA 08/2021
1	SolutionsIBA 10/2018
1	Triamcinolone (Aristocort)FDA Link 04/2015
1	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 01/2014
1	Glutamic Acid (Glutamate)FDA Link 01/2013
1	Sodium Channels (Sodium Channel)IBA 01/2013
1	EtoricoxibIBA 05/2010
1	Oxymorphone (Numorphan)FDA LinkGeneric 02/2009
1	Celecoxib (Celebrex)FDA Link 12/2008
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2008
1	SteroidsIBA 11/2006
1	Naproxen (Naprosyn)FDA LinkGeneric 08/2006
1	Gabapentin (Neurontin)FDA LinkGeneric 01/2004
1	Tramadol (K315)FDA LinkGeneric 03/2003
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 03/2003

Therapy/Procedure

3	Aftercare (After-Treatment) 01/2022 - 11/2006
3	Injections 07/2015 - 01/2014
2	Therapeutics 05/2010 - 09/2004
1	Physical Therapy Modalities (Physical Therapy Technique) 01/2014
1	Oral Surgery (Maxillofacial Surgery) 03/2003